So what happens if you started from your house to go to the supermarket and programmed your car that way. Just after it started you remembered that you need to stop by at the hardware store round the corner. With a manual car, it is a non-issue, but with an autonomously driving car, you will need to disengage and re-engage?
Wait till they come up with an autonomous mind-readiing car that senses your wire wrapped brain and analyses signals and reroutes itself. Do machines get annoyed?